Not sure about a guide but my normal loadout consists of 4 250lbs bombs armed with the No28 MkIIx Pistol - Ever Ready
When skip bombing I use a 11 second charging delay otherwise 0 seconds.
Can't remember them not going off.
Are you using them in single player or on-line?
To get your load outs to apply you need to set them in multiplayer or by starting the mission in the Full Mission Builder. Once they have been set there they can be used in single missions.
Cheers!
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