the most have deactivated it i guess

, anyway.
As examples with the Bf110 and Bf109E-1&-3, when you have this setting enabled one is able to control stick, throttle and pitchlevers at the same time. in these aircraft that would mean you have three arms

so , pitch and throttle have to be seperated with antropomorph 'on' with these planes.
And IIRC in the Ju 88 and He111 too.
For the FIATs i have to check the cockpits again.