I personally have a GTX 460 which will play the game around 25-35 FPS (I don't know the exact but that's my estimation) on all Medium Settings, a couple on High, and nothing turned off. It only lags if there is a big fireball nearby or the wind dust effect behind you as well as the crashes in water from External view. It runs much smoother at something lower than my native resolution: 1920 by 1200. Hope this helps and sorry for the wall of text.
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