I have 1 8800 GTX 512 PCI-Express video card. It will probably work fine, and it's a single standalone card. My Mobo will support 3 SLI, but when I researched carefully there was not benefit for 3 cards. More heat was about the whole of it.
I wouldn't sweat it now, because there will be a rush from this community upon final release. Many people will want to get the best out of the SOW possible, and I really don't think it's worth worrying about until such time.
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